Part One follows several different people over the same period of several days. Several of the characters from the two previous books appear, including Armand, Daniel (the "boy reporter" of Interview with the Vampire), Marius, Louis, Gabrielle and Santino. Each of the six chapters in Part One tells a different story about a different person or group of people. Two things unify these chapters: a series of dreams about red-haired twin sisters, and the fact that a powerful being is killing vampires around the world by means of spontaneous combustion.Pandora and Santino rescue Marius, having answered his telepathic call for help. Marius informs his rescuers that Akasha has been awakened by Lestat, or rather his rock music, for he has joined a rock band of mortals whose names are Alex, Larry and Tough Cookie. Having been awakened by Lestat's rebellious music, Akasha destroys her husband Enkil and plots to rule the world. Akasha is also revealed as the source of the attacks on other vampires.Part Two takes place at Lestat's concert. Jesse Reeves, a member of the secret Talamasca and relative of Maharet, is mortally injured while attending the concert, and is taken to Maharet's Sonoma compound where she is made into a vampire. The vampires from Part One later congregate in the Sonoma compound. The only vampires not present are Akasha and Lestat. Akasha has abducted Lestat and takes him as an unwilling consort to various locations in the world, inciting women to rise up and kill the men who have oppressed them.Part Three takes place at Maharet's home in a Sonoma forest. There Maharet tells the story of Akasha and the red-haired twins (who are, in fact, Maharet and her sister, Mekare) to Pandora, Jesse, Marius, Santino, Eric, Armand, Daniel, Louis and Gabrielle. Also present are Mael and Khayman, who already know the story.Further information on their story: Maharet and MekareIn Part Four, Akasha confronts the gathered vampires at Maharet's compound. There she explains her plans and offers the vampires a chance to be her "angels" in her New World Order. Akasha plans to kill 90 percent of the world's human men, and to establish a new Eden in which women will worship Akasha as a goddess. If the assembled vampires refuse to follow her, she will destroy them. The vampires refuse, but before Akasha can destroy them, Mekare enters. Mekare kills Akasha by severing her head and then consumes Akasha's brain and heart. Amel passes into Mekare, thereby saving the lives of the remaining vampires. She becomes the new Queen of the Damned.In Part Five, the vampires leave Maharet's compound and assemble at Armand's resort, the Night Island, (according to Anne Rice, inspired by Fire Island) in Florida to recover. They eventually go their separate ways (as told in The Tale of the Body Thief). Lestat takes Louis to see David Talbot in London. After their brief visit with Talbot they depart into the night, an incensed Louis and his angry words filling Lestat with glee.